{
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        {
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          "time_hours": 0.0
        },
        {
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          "time_hours": 96.0
        }
      ],
      "evidence": [],
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      "schedule_id": "myoblast-proliferation-to-differentiation-v1",
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    "initial_total_billion_cells": 0.004,
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      "perturbations": [],
      "schedule_id": "none",
      "schema_version": "zentari.cell.perturbation-schedule.v1"
    },
    "product_maturity": "L0",
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      "cell_line": null,
      "evidence": [],
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          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
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          "upper_bound": null,
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        },
        "baseline_death_rate_per_hour": {
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          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
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        },
        "glucose_consumption_mmol_per_billion_cells_hour": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
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          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
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          "upper_bound": null,
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        },
        "glucose_half_saturation_mmol_l": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "mmol/litre",
          "upper_bound": null,
          "value": 0.15
        },
        "lactate_growth_inhibition_mmol_l": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "mmol/litre",
          "upper_bound": null,
          "value": 20.0
        },
        "lactate_severe_mmol_l": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "mmol/litre",
          "upper_bound": null,
          "value": 42.0
        },
        "lactate_yield_mmol_per_mmol_glucose": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "mmol/mmol",
          "upper_bound": null,
          "value": 1.8
        },
        "max_growth_rate_per_hour": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
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          "upper_bound": null,
          "value": 0.035
        },
        "oxygen_consumption_mmol_per_billion_cells_hour": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
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          "unit": "mmol/(billion_cells*hour)",
          "upper_bound": null,
          "value": 0.36
        },
        "oxygen_half_saturation_fraction": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "fraction",
          "upper_bound": null,
          "value": 0.1
        },
        "reference_temperature_c": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": null,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "degree_celsius",
          "upper_bound": null,
          "value": 37.0
        },
        "schema_version": "zentari.cell.kinetic-parameters.v1",
        "senescence_doubling_limit": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "population_doubling",
          "upper_bound": null,
          "value": 50.0
        },
        "shear_death_coefficient_per_hour_pa": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "1/(hour*pascal)",
          "upper_bound": null,
          "value": 0.02
        },
        "shear_death_threshold_pa": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
          "source_class": "literature_prior",
          "standard_uncertainty": null,
          "unit": "pascal",
          "upper_bound": null,
          "value": 1.5
        },
        "temperature_q10": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.01,
          "schema_version": "zentari.cell.sourced-float.v1",
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          "standard_uncertainty": null,
          "unit": "dimensionless",
          "upper_bound": null,
          "value": 2.0
        }
      },
      "lineage": "myogenic progenitor",
      "morphology": "adherent myoblast-like progenitor with fused differentiated product",
      "profile_id": "generic_mammalian_myoblast",
      "profile_version": "1.0.0",
      "schema_version": "zentari.cell.profile.v1",
      "species": "generic mammal",
      "states": [
        {
          "harvestable": false,
          "initial_fraction": 0.1,
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          "schema_version": "zentari.cell.state-definition.v1",
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        },
        {
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          "initial_fraction": 0.9,
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          "metabolically_active": true,
          "proliferative": true,
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        },
        {
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        },
        {
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          "schema_version": "zentari.cell.state-definition.v1",
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        },
        {
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          "schema_version": "zentari.cell.state-definition.v1",
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        },
        {
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          "proliferative": false,
          "schema_version": "zentari.cell.state-definition.v1",
          "state_id": "senescent",
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        },
        {
          "harvestable": false,
          "initial_fraction": 0.0,
          "kind": "apoptotic",
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          "proliferative": false,
          "schema_version": "zentari.cell.state-definition.v1",
          "state_id": "apoptotic",
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        },
        {
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          "initial_fraction": 0.0,
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          "proliferative": false,
          "schema_version": "zentari.cell.state-definition.v1",
          "state_id": "necrotic",
          "viable": false
        },
        {
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          "initial_fraction": 0.0,
          "kind": "dead",
          "metabolically_active": false,
          "proliferative": false,
          "schema_version": "zentari.cell.state-definition.v1",
          "state_id": "dead",
          "viable": false
        }
      ],
      "tissue": "skeletal muscle",
      "transitions": [
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
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            "schema_version": "zentari.cell.sourced-float.v1",
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            "value": 0.012
          },
          "driver": "growth_cue",
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          "transition_id": "quiescent_to_proliferating"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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            "schema_version": "zentari.cell.sourced-float.v1",
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            "value": 0.008
          },
          "driver": "nutrient_stress",
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          "transition_id": "proliferating_to_quiescent"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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          },
          "driver": "differentiation_cue",
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          "schema_version": "zentari.cell.transition-definition.v1",
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          "transition_id": "proliferating_to_differentiating"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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            "schema_version": "zentari.cell.sourced-float.v1",
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            "value": 0.01
          },
          "driver": "maturation_cue",
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          "schema_version": "zentari.cell.transition-definition.v1",
          "source_state": "differentiating",
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          "transition_id": "differentiating_to_mature"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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            "schema_version": "zentari.cell.sourced-float.v1",
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            "value": 0.025
          },
          "driver": "general_stress",
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          "schema_version": "zentari.cell.transition-definition.v1",
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          "transition_id": "proliferating_to_stressed"
        },
        {
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            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
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            "value": 0.01
          },
          "driver": "recovery",
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          "schema_version": "zentari.cell.transition-definition.v1",
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          "target_state": "proliferating",
          "transition_id": "stressed_to_proliferating"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
            "lower_bound": 0.0,
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            "value": 0.02
          },
          "driver": "senescence",
          "max_rate_per_hour": null,
          "reversible": false,
          "schema_version": "zentari.cell.transition-definition.v1",
          "source_state": "proliferating",
          "target_state": "senescent",
          "transition_id": "proliferating_to_senescent"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "assumed",
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            "unit": "1/hour",
            "upper_bound": null,
            "value": 0.01
          },
          "driver": "apoptosis",
          "max_rate_per_hour": null,
          "reversible": false,
          "schema_version": "zentari.cell.transition-definition.v1",
          "source_state": "stressed",
          "target_state": "apoptotic",
          "transition_id": "stressed_to_apoptotic"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "assumed",
            "standard_uncertainty": null,
            "unit": "1/hour",
            "upper_bound": null,
            "value": 0.02
          },
          "driver": "necrosis",
          "max_rate_per_hour": null,
          "reversible": false,
          "schema_version": "zentari.cell.transition-definition.v1",
          "source_state": "stressed",
          "target_state": "necrotic",
          "transition_id": "stressed_to_necrotic"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
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            "unit": "1/hour",
            "upper_bound": null,
            "value": 0.05
          },
          "driver": "constant",
          "max_rate_per_hour": null,
          "reversible": false,
          "schema_version": "zentari.cell.transition-definition.v1",
          "source_state": "apoptotic",
          "target_state": "dead",
          "transition_id": "apoptotic_to_dead"
        },
        {
          "base_rate_per_hour": {
            "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
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            "upper_bound": null,
            "value": 0.1
          },
          "driver": "constant",
          "max_rate_per_hour": null,
          "reversible": false,
          "schema_version": "zentari.cell.transition-definition.v1",
          "source_state": "necrotic",
          "target_state": "dead",
          "transition_id": "necrotic_to_dead"
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      ],
      "transport": {
        "dissolved_oxygen_saturation_mol_m3": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
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          "unit": "mol/metre^3",
          "upper_bound": null,
          "value": 0.21
        },
        "glucose_diffusivity_tissue_m2_s": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
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          "standard_uncertainty": null,
          "unit": "metre^2/second",
          "upper_bound": null,
          "value": 7e-10
        },
        "kinematic_viscosity_medium_m2_s": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
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          "standard_uncertainty": null,
          "unit": "metre^2/second",
          "upper_bound": null,
          "value": 7e-07
        },
        "oxygen_diffusivity_medium_m2_s": {
          "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
          "evidence": [],
          "lower_bound": 0.0,
          "schema_version": "zentari.cell.sourced-float.v1",
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          "standard_uncertainty": null,
          "unit": "metre^2/second",
          "upper_bound": null,
          "value": 2.5e-09
        },
        "oxygen_diffusivity_tissue_m2_s": {
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          "evidence": [],
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          "upper_bound": null,
          "value": 2e-09
        },
        "schema_version": "zentari.cell.transport-parameters.v1",
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          "schema_version": "zentari.cell.sourced-float.v1",
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          "unit": "dimensionless",
          "upper_bound": null,
          "value": 4.0
        }
      }
    },
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        },
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        "trace_digest_sha256": "7d87ae1eed355db4c3edf106c4706cc68c0d03522e6d7e46959c3a803a0e0d7b"
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    ],
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      },
      "duration_hours": 168.0,
      "engine_fidelity": "Cell-F1",
      "environment": {
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          {
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            "schema_version": "zentari.cell.environment-control-point.v1",
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              "porosity": 0.65,
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              "schema_version": "zentari.cell.environment-conditions.v1",
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              "temperature_c": 37.0,
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              "viscosity_pa_s": 0.001
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            "time_hours": 0.0
          },
          {
            "medium_exchange_rate_per_hour": 6.0,
            "schema_version": "zentari.cell.environment-control-point.v1",
            "target": {
              "acoustic_intensity_w_cm2": 0.0,
              "amino_acids_fraction": 1.0,
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              "electric_field_v_m": 0.0,
              "glucose_mmol_l": 25.0,
              "growth_cue": 0.25,
              "lactate_mmol_l": 0.0,
              "magnetic_field_t": 0.0,
              "matrix_stiffness_kpa": 12.0,
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              "optical_intensity_w_cm2": 0.0,
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              "oxygen_fraction": 1.0,
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              "porosity": 0.65,
              "pressure_pa": 101325.0,
              "schema_version": "zentari.cell.environment-conditions.v1",
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              "temperature_c": 37.0,
              "velocity_um_s": 10.0,
              "viscosity_pa_s": 0.001
            },
            "time_hours": 96.0
          }
        ],
        "evidence": [],
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        "schedule_id": "myoblast-proliferation-to-differentiation-v1",
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      "perturbations": {
        "perturbations": [],
        "schedule_id": "none",
        "schema_version": "zentari.cell.perturbation-schedule.v1"
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      "product_maturity": "L0",
      "profile": {
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        "applicability_domain": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
        "cell_line": null,
        "evidence": [],
        "kinetics": {
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            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
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            "upper_bound": null,
            "value": 0.02
          },
          "baseline_death_rate_per_hour": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
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            "unit": "1/hour",
            "upper_bound": null,
            "value": 0.002
          },
          "glucose_consumption_mmol_per_billion_cells_hour": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
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            "unit": "mmol/(billion_cells*hour)",
            "upper_bound": null,
            "value": 0.18
          },
          "glucose_half_saturation_mmol_l": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
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            "unit": "mmol/litre",
            "upper_bound": null,
            "value": 0.15
          },
          "lactate_growth_inhibition_mmol_l": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
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            "unit": "mmol/litre",
            "upper_bound": null,
            "value": 20.0
          },
          "lactate_severe_mmol_l": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "mmol/litre",
            "upper_bound": null,
            "value": 42.0
          },
          "lactate_yield_mmol_per_mmol_glucose": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "mmol/mmol",
            "upper_bound": null,
            "value": 1.8
          },
          "max_growth_rate_per_hour": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "1/hour",
            "upper_bound": null,
            "value": 0.035
          },
          "oxygen_consumption_mmol_per_billion_cells_hour": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "mmol/(billion_cells*hour)",
            "upper_bound": null,
            "value": 0.36
          },
          "oxygen_half_saturation_fraction": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "fraction",
            "upper_bound": null,
            "value": 0.1
          },
          "reference_temperature_c": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": null,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "degree_celsius",
            "upper_bound": null,
            "value": 37.0
          },
          "schema_version": "zentari.cell.kinetic-parameters.v1",
          "senescence_doubling_limit": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "population_doubling",
            "upper_bound": null,
            "value": 50.0
          },
          "shear_death_coefficient_per_hour_pa": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "1/(hour*pascal)",
            "upper_bound": null,
            "value": 0.02
          },
          "shear_death_threshold_pa": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.0,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "pascal",
            "upper_bound": null,
            "value": 1.5
          },
          "temperature_q10": {
            "applicability": "Order-of-magnitude mammalian/myoblast culture prior for deterministic scenario comparison only; not calibrated to a named cell line, scaffold, medium, or laboratory.",
            "evidence": [],
            "lower_bound": 0.01,
            "schema_version": "zentari.cell.sourced-float.v1",
            "source_class": "literature_prior",
            "standard_uncertainty": null,
            "unit": "dimensionless",
            "upper_bound": null,
            "value": 2.0
          }
        },
        "lineage": "myogenic progenitor",
        "morphology": "adherent myoblast-like progenitor with fused differentiated product",
        "profile_id": "generic_mammalian_myoblast",
        "profile_version": "1.0.0",
        "schema_version": "zentari.cell.profile.v1",
        "species": "generic mammal",
        "states": [
          {
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            "schema_version": "zentari.cell.state-definition.v1",
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          },
          {
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            "initial_fraction": 0.9,
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          },
          {
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          },
          {
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            "schema_version": "zentari.cell.state-definition.v1",
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          {
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          },
          {
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            "schema_version": "zentari.cell.state-definition.v1",
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          },
          {
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          },
          {
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            "schema_version": "zentari.cell.state-definition.v1",
            "state_id": "necrotic",
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          },
          {
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            "schema_version": "zentari.cell.state-definition.v1",
            "state_id": "dead",
            "viable": false
          }
        ],
        "tissue": "skeletal muscle",
        "transitions": [
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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              "schema_version": "zentari.cell.sourced-float.v1",
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              "value": 0.012
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          },
          {
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              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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              "schema_version": "zentari.cell.sourced-float.v1",
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            "driver": "nutrient_stress",
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          {
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              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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          },
          {
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              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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            },
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            "source_state": "differentiating",
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            "transition_id": "differentiating_to_mature"
          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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              "schema_version": "zentari.cell.sourced-float.v1",
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              "value": 0.025
            },
            "driver": "general_stress",
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          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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              "schema_version": "zentari.cell.sourced-float.v1",
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              "value": 0.01
            },
            "driver": "recovery",
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            "schema_version": "zentari.cell.transition-definition.v1",
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          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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              "schema_version": "zentari.cell.sourced-float.v1",
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              "value": 0.02
            },
            "driver": "senescence",
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            "schema_version": "zentari.cell.transition-definition.v1",
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          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
              "evidence": [],
              "lower_bound": 0.0,
              "schema_version": "zentari.cell.sourced-float.v1",
              "source_class": "assumed",
              "standard_uncertainty": null,
              "unit": "1/hour",
              "upper_bound": null,
              "value": 0.01
            },
            "driver": "apoptosis",
            "max_rate_per_hour": null,
            "reversible": false,
            "schema_version": "zentari.cell.transition-definition.v1",
            "source_state": "stressed",
            "target_state": "apoptotic",
            "transition_id": "stressed_to_apoptotic"
          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
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              "lower_bound": 0.0,
              "schema_version": "zentari.cell.sourced-float.v1",
              "source_class": "assumed",
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              "unit": "1/hour",
              "upper_bound": null,
              "value": 0.02
            },
            "driver": "necrosis",
            "max_rate_per_hour": null,
            "reversible": false,
            "schema_version": "zentari.cell.transition-definition.v1",
            "source_state": "stressed",
            "target_state": "necrotic",
            "transition_id": "stressed_to_necrotic"
          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
              "evidence": [],
              "lower_bound": 0.0,
              "schema_version": "zentari.cell.sourced-float.v1",
              "source_class": "assumed",
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              "unit": "1/hour",
              "upper_bound": null,
              "value": 0.05
            },
            "driver": "constant",
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            "reversible": false,
            "schema_version": "zentari.cell.transition-definition.v1",
            "source_state": "apoptotic",
            "target_state": "dead",
            "transition_id": "apoptotic_to_dead"
          },
          {
            "base_rate_per_hour": {
              "applicability": "Structural launch assumption used to exercise the configurable state graph; rate requires calibration or measured evidence before biological promotion.",
              "evidence": [],
              "lower_bound": 0.0,
              "schema_version": "zentari.cell.sourced-float.v1",
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              "unit": "1/hour",
              "upper_bound": null,
              "value": 0.1
            },
            "driver": "constant",
            "max_rate_per_hour": null,
            "reversible": false,
            "schema_version": "zentari.cell.transition-definition.v1",
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